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However, tunicamycin induces ER stress through a different mechanism, by inhibiting N-linked glycosylation, a critical step in glycoprotein synthesis, leading to the accumulation of misfolded proteins specifically within the ER 46,47
Why Pressure Balance Matters When Reconstituting Peptides When liquid is added to a vial, internal pressure changes
This finding supports previous observations of synergistic effect of GLS-1 and MCL-1 inhibition
References 1.Newton K, Strasser A, Kayagaki N, Dixit VM
