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doi: 10.1080/10495398.2018.1437046 96 OlivaresRPostmaGCSchapiraAIglesiasDEValdezLBBreiningerEet al

Gliotoxin was administrated to female C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein with a dose of 1 mg/kg, which can aggravate the symptom of neuroinflammation via the upregulation of inflammatory genes, including T-box transcription factor (TBX21), inducible nitric oxide synthase (iNOS), arginase 1 (ARG1), and cytokines such as IFN-, IL-17, and IL-2 [48]