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PE-22-28's cognitive potential is inferred from antidepressant tests and TREK-1 KO phenotypes Oral bioavailability : Dihexa demonstrates 38% oral bioavailability

4.3 Oxidative stress promotes the progression of diabetes toward diabetic cognitive dysfunction Cognitive impairment is one of the complications of diabetes, characterized by structural and pathological changes in the brain, and increasing research indicates that oxidative stress plays a pivotal role in cognitive impairment (42)

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Regulatory scrutiny has intensified, and the FDA has stepped in to limit many uses