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However, in later stages, both NO- and EDHF-induced vasodilation may eventually be impaired, resulting in microvascular dysfunction (41)

This imbalance should be avoided for cellular processes to remain regulated

Liver cirrhosis represents a post-injury liver repair response wherein hepatic stellate cell (HSC) activation plays a pivotal role, alongside liver sinusoidal endothelial cells (LSECs) regulation, cytokine release, and fibrous scar tissue deposition (Kisseleva and Brenner, 2021)