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Description
Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment
To further confirm this hypothesis, DEN/CCl4-induced liver cancer xenograft mice were administered piperazine erastin in the presence and absence of Lip-1
The formation of this mercapturic acid primarily occurs in the liver, which is the main site of drug metabolism in the body
(Mittler, 2017) (Figure 2)
