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The amino acid residues that make up the H-site are involved in recognizing and binding various exogenous and endogenous compounds and positioning their electrophilic centers for attack by the nucleophilic GSH

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This process is facilitated by the activity of the metalloreductases six-transmembrane epithelial antigen of the prostate (STEAP) and duodenal cytochrome b (DCYTB), 6,7 which reduce divalent Cu 2+ to monovalent Cu +

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Therefore, exosome-mediated communication between tumor cells and stromal cells is a bidirectional process (Fig

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F., Gray, T

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