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The amino acid residues that make up the H-site are involved in recognizing and binding various exogenous and endogenous compounds and positioning their electrophilic centers for attack by the nucleophilic GSH

This process is facilitated by the activity of the metalloreductases six-transmembrane epithelial antigen of the prostate (STEAP) and duodenal cytochrome b (DCYTB), 6,7 which reduce divalent Cu 2+ to monovalent Cu +

Therefore, exosome-mediated communication between tumor cells and stromal cells is a bidirectional process (Fig

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