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The VEGFR2-Akt-eNOS signaling pathway was directly activated (i.e., without the need for other known ligands or shear stress), controlling vasomotor tone (both smooth muscle and endothelium), and the Src-Caveolin-1-eNOS pathway was activated [103,104]

PMID: 15452611

Mechanistic potential does not guarantee clinical benefit Rodent studies show BPC-157 may influence angiogenesis, fibroblast behavior, nitric oxide signaling, tendon remodeling, and inflammatory pathways (Park, 2025)

In practice, using bacteriostatic water as a diluent for a single-dose medication in a nursing mother is unlikely to pose significant risk, but caution is still advised