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Cytoplasmic, bioavailable zinc is essential for IL-1 production in activated human monocytes and macrophages, acting downstream of glycolysis, which is induced by the mammalian target of rapamycin complex 1 (mTORC1)

Redox proteomics indicate that SS-31 reverses oxidative modifications of focal adhesion molecules near the plasma membrane and myelin sheath proteins surrounding motor neurons, suggesting that mitochondrial redox biology influences cellular structures far beyond the mitochondria themselves

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