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In the case of these conjugates, it was likely that their binding was a consequence of the catalytic activity of the ligandin, with At GSTU19 previously shown to catalyze the glutathionylation of OPDA ( Binding and Inhibition of GSTs by in vivo Ligands To investigate the binding characteristics of the ligands to the GSTs, isothermal titration calorimetry (ITC) was used to determine binding affinity and stoichiometry

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Figure 1 It is well known that antipsychotic drugs commonly cause serious extrapyramidal side effects (EPS) (e.g., bradykinesia, muscle rigidity, tremor, and akathisia) by blocking dopamine D 2 receptors in the striatum (Remington and Kapur, 1999