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This understanding suggests that effective therapeutic strategies must consider targeting multiple points of ROS generation or enhancing systemic antioxidant capacity to achieve comprehensive redox balance

Studies have shown that the Trx and GSH/Grx systems are specific to different organelles in neurons and glial cells and regulate redox signaling and that thiol-disulfide bond conversion (GSH) occurs in two states: oxidized and reduced (Horibe et al., 2001)
Lee SC, Choi DS, Hwang IS, Hwang BK

Acids 58 , 257263 (1998)