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Mechanistically, impaired iron exporte.g., zinc-mediated inhibition of amyloid precursor protein (APP) ferroxidase activityprovides a route to local iron accumulation (Duce et al., 2010), while familial AD presenilin mutations confer selective vulnerability to ferroptosis in human neuronal models (Greenough et al., 2022)
CarstensADicksvedJNelsonRLindqvistMAndreassonABohrJet al
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The eXpress diagnostic modeling environment is essential for determining the diagnostic designs ability to Uniquely Isolate any failures (or loss of function)
