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Clinical studies demonstrate an association of excess 25-hydroxy-vitamin D deficiency with the severity and outcome of patients infected with COVID-19 [3,[107], [108], [109], [110], [111]]

Since MTHFR controls the detoxification of homocysteine and the supply of methyl groups for SAM synthesis, a reduction in its activity can affect homocysteine metabolism and disturb cellular methylation processes

However, because of their high content of dietary nitrates, there is some evidence that beetroot powder benefits brain health and may help protect against age-related cognitive decline