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Common covered indications include recurrent pregnancy loss, unexplained blood clots (thrombosis), family history of MTHFR-related cardiovascular disease, or elevated homocysteine confirmed on a blood panel

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Moreover, in some species, such as mice, this increase may not occur at all

Although, TGFB1 secretion is known to play a crucial role in cornea injury responses and the activation of keratinocytes in the corneal stroma 30 , additional investigation is needed to determine whether the downregulation of TGFB1 gene expression has any impact on DES