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Dysregulation of mitochondrial calcium (mtCa) uptake, particularly due to MICU1 deficiency, leads to progressive muscle weakness and atrophy in both patients and mouse models [293]

Men, younger on average, exhibited distinct echocardiographic differences, including lower left ventricular ejection fraction, larger left ventricular end-systolic volume, and smaller aortic valve area index than women (547% vs

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The treatment diminished triacylglycerol in muscle and plasma, decreased hepatic steatosis, and normalized CPT1, improving ACC and fatty acid synthase [86]