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These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Kasarello et al., 2023)

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Audet N, Gales C, Archer-Lahlou E, Vallieres M, Schiller PW, Bouvier M, Pineyro G: Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric g proteins

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