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The innate immune system also influences immune imbalance in vitiligo by regulating Treg cell function and numbers

Toxicol 94(8):260323 [DOI] [PubMed] [Google Scholar] 82.Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, et al

Glutathion S-transferases (GSTs), an eukaryotic and prokaryotic phase II metabolic isozymes-family, catalyze the conjugation of reduced form of gluthatione (GSH, nucleophil) and xenobiotics (electrophil) to gluthatione-S-Conjugate via nucleophilic attack (see Figure 4)

These reactive compounds interact with amino groups (NH 2 ) in proteins and DNA bases, leading to the formation of adducts that can cause mutations (Yang et al., 2019)