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While the majority of published data originates from the Sikiric laboratory in Zagreb, independent groups have increasingly contributed to the literature, and the peptide remains a subject of active investigation across multiple areas of preclinical science.

IDH2 is encoded by the IDH2 gene which is located on chromosome 15q26.1 and is composed of 12 exons that generate three alternatively spliced mRNAs, each of which encode a distinct protein isoform