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Preclinical studies in flies demonstrated that supplementation with NR or NMN improved mitochondrial respiration and membrane potential, and exercise endurance was improved 304,305
It is believed that the Werner syndrome (WS), which is characterized by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, most closely resembles the aging process (23)
PubMed Neelakantan H, Wang HY, Vance V, et al

Deeper metabolic changes fat burning, endurance typically become measurable at eight to twelve weeks of consistent use