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Chichanovskaya LV, Bakhareva ON, Sorokina KB
Compounds that affect brain chemistry: Use caution when combining 5-HTP with medications or supplements that affect amino acid production, like carbidopa, St Johns wort, and SAM-e
It enhances the expression of glioma stem cell (GSC) markers, fostering tumor growth through paracrine actions that involve angiogenic factors controlled by HIFs, particularly HIF-2 ( 4.3.4 Glutathione Elevated glutathione levels in GB lead to reduced oxidative stress which is crucial for disease progression ( 4.3.5 Altered drug mechanism of action Repurposed drugs may exert their effect on the CNS tumor differently from their actions in the originally FDA-approved tumor type ( The cumulative effect of all these features is a selective pressure favoring the growth of resistant clones, complicating future therapies, whether targeted or otherwise

Shoot Low
