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Most recently, a randomized, placebo-controlled trial in 40 obese men (ages, 40-70 years) found that daily supplementation with nicotinamide riboside (2,000 mg/day divided into two daily dosages) for 12 weeks was associated with reports of only minor side effects, including excessive sweating, pruritus, and mild gastrointestinal symptoms like bloating (139)

Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation

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However, it is important to note that neurological symptoms can occur even in the absence of anaemia, particularly in patients taking folic acid supplements, which can mask the blood changes whilst neurological damage progresses