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Description
Symptom reduction rather than elimination is realistic for most

Wakelin S, Page D, Dillon P, Pavelic P, Abell GCJ, Gregg AL, Brodie E, DeSantis TZ, Goldfarb KC, Anderson G (2011) Microbial community structure of a slow sand filter Schmutzdecke: a phylogenetic snapshot based on rRNA sequence analysis

It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60
