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Moreover, TN-C increased infiltration of Treg cells, and ablation of TN-C inhibited immune-suppressive stromal properties in an OSCC model [143]

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To achieve this, an adeno-associated virus (AAV) carrying the inhibitory hM4Di receptor under the control of the GABAergic neuron promoter (AAV-VGAT-hM4D(Gi)-mCherry) or an AAV-VGAT-mCherry as a control was injected into the bilateral APC of C57 mice
