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As we navigate our wellness journeys, understanding the intersections between our daily choices becomes crucial

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Role of IGF-1 in renal ischemia Post-ischemic regeneration leads to increased renal IGF-1 expression, promoting proliferation of tubular and non-tubular cells at the kidney regenerative zones by binding IGF1R.32 Studies using animal models of ischemic acute renal injury have shown that IGF-1 administration is useful to reduce renal protein catabolism, resulting in enhanced renal cell proliferation, accelerated recovery of renal function, and improved kidney histology.33,34 These regenerative effects after ischemia-induced acute tubular necrosis are also achieved by exogenous administration of recombinant IGF-1, resulting in a lower mortality in comparison with animals treated with vehicle or GH.34,35 However, despite these promising results in animal models, administration of recombinant IGF-1 (100g/12h