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[DOI] [PubMed] [Google Scholar] Pichon C., Goncalves C

Why this trial matters: First triple hormone receptor agonist showing major Phase III weight-loss efficacy Delivers weight-loss outcomes far beyond many current therapies Suggests a potential new metabolic and obesity care benchmark Semaglutide Shows Consistent Liver Benefits in MASH In the Phase III ESSENCE study, once-weekly semaglutide 2.4 mg significantly increased rates of steatohepatitis resolution and fibrosis improvement on liver biopsy in adults with metabolic dysfunction-associated steatohepatitis (MASH), compared with placebo

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After reconstitution with bacteriostatic water, the solution should be refrigerated and used within 28-30 days