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The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network

Ecotox 18:385402 Hahn ME, Hestermann EV (2008) Receptor-mediated mechanisms of toxicity

Following ingestion of 888mg GABA in 1 liter of water, the pharmacokinetic variables were: t max (h) = 0.5 and the C max (ng/ml) = 75

Nutritional interventions targeting Polyunsaturated fatty acids (PUFAs) and gut microbiota demonstrate substantial metabolic benefits through multiple mechanisms
