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Accumulating extra-synaptic glutamate due to the over-activation of microglia promotes aberrant synaptic signaling in PD and other neurodegenerative brain diseases (Iovino et al

This phenomenon leads to increased expression of intracellular inflammatory factors, such as IL-6, IL-1, and TNF-, resulting in endocytosis and degradation of FPN1 regulated by hepcidin (Qian et al

Mercury, lead, cadmium, and arsenic can bioaccumulate in tissues and silently disrupt the bodys most fundamental systems: energy metabolism, immune regulation, and neurological resilience
