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These findings positioned DHODH as a third axis of ferroptosis defense, alongside GPX4 and FSP1, particularly in mitochondria-rich or metabolically active cell types

NRF2-mediated target gene expression is determined by the activating stimulus, the cellular context, the availability of binding partners, interaction with other transcription factors, activators, and repressors, as well as the crosstalk with other signaling pathways

"Patients with the very mildest symptoms of Alzheimer's will likely have the greatest benefit and the least risk of adverse events from treatment," said Snider, who led clinical trials for lecanemab at WashU Medicine
