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10.1042/BJ20060034 25 GonzalezD.FraichardS.GrasseinP.DelarueP.SenetP.NicolaA.et al (2018)

Additionally, the activation of genes implicated in ferroptosis is significantly upregulated in retinal tissue in spontaneous dry age-related macular degeneration (SD-AMD), suggesting that the disruption of iron homeostasis and ferroptosis could significantly influence disease onset and development (251)

These experimental data demonstrated that the EGCG-Zn suppository exhibited good biocompatibility and an acceptable safety profile during the evaluated treatment period, supporting its potential suitability for localized rectal administration

This distinction matters most for patients whose primary goal is systemic detoxification alongside oxygenation support rather than a single targeted injection