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In animal studies, systemic TB-500 administration improved cardiac muscle survival post-infarction, enhanced dermal and corneal repair, and reduced inflammatory cytokines in sepsis and neural injury models

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Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases

Ng FM, Sun J, Sharma L, Libinaki R, Jiang WJ, Gianello R