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Description
The initial step for the de nov o synthesis of GSH occurs through the activity of glutamate-cysteine ligase, a heterodimer of a catalytic subunit and a modifier subunit that catalyses the first and rate-limiting step to form the dipeptide -glutamylcysteine from cysteine and glutamate (Reference Desideri, Ciccarone and Ciriolo27)

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DOI: 10.1097/00005176-200009000-00016 10

10.1016/j.lfs.2005.09.040 228
