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Some clear triggers to stop and contact a clinician include: New or worsening hypothyroid symptoms or an unexpected rise in TSH Unexplained INR instability if you are on warfarin New seizures or increased seizure frequency Evidence gaps and how clinicians can manage uncertainty Large randomized trials of supplement-drug interactions are rare

Front Mol Biosci 9:1016352 [DOI] [PMC free article] [PubMed] [Google Scholar] 126.Taquet M, Sillett R, Zhu L, Mendel J, Camplisson I, Dercon Q, Harrison PJ (2022) Neurological and psychiatric risk trajectories after SARS-COV-2 infection: an analysis of 2-year retrospective cohort studies including 1,284,437 patients

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