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doi: 10.1089/neu.2008.0858 147 KatzenbergerRJChtarbanovaSRimkusSAFischerJAKaurGSeppalaJMet al

Inhibition of mTORC1 restored autophagy in cells treated with these drugs, helping cancer cells bypass the blockage of phosphorylation of the E1 subunit of PDH and making it a potential therapeutic target in tumor cells that are resistant to mTOR-mediated therapies

In breast cancer cells, NF-B activation can inhibit -catenin/TCF activity, thus negatively regulating the Wnt/-catenin pathway (Ma and Hottiger, 2016)

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