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Zoricic, I

1 Introduction Chimeric antigen receptor T (CAR-T) cell therapy is a pivotal innovation in the field of targeted immunotherapy, allowing for the direct recognition of tumor-associated antigens (TAAs) without requiring major histocompatibility complex (MHC)-mediated antigen presentation ( SLE is a severe autoimmune disorder, affecting primarily women of childbearing age with a prevalence of 0.1% in the general population ( With the advancement of innovative immunotherapies, CAR T-cell therapy holds great potential for treating patients with refractory SLE ( + B cells or BCMA + plasma cells or double-positive plasmablasts ( Taken together, this review aims to evaluate the potential of CAR-T cell therapy in treating SLE\-related diseases

Substitution of three aromatic residues with threonine (W385T), tyrosine (F417Y), and alanine (W525A), present at the corresponding positions in EcGGT, resulted in enhanced transpeptidase activity for all three mutants, while a 514% decrease in hydrolytic activity was observed

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