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[13] [14] Deficiency impairs these pathways, leading to fatigue and reduced stamina One-carbon metabolism : B12 supports methylation reactions that contribute to various biochemical processes throughout the body Myelin formation : B12 supports the maintenance of myelin sheaths surrounding nerve fibres, ensuring efficient nerve signal transmission Red blood cell production : Adequate B12 is necessary for erythropoiesis

Loading regimens involve 1 mg three times weekly for two weeks, or alternate-day dosing if neurological symptoms are present

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Methylcobalamin works in the cell plasma, whilst adenosylcobalamin is only active in the mitochondria