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Most of the anti-inflammatory effects of PPARs result from their inhibition of the NF-B signaling pathway, which also inhibits the production of various genes implicated in the inflammatory response, including iNOS, IL-6, and IL-12 58
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A non-substrate competitive inhibitor, PF-9366, showed promise with a higher potency for MAT2A
doi: 10.3892/etm.2013.1434
