nebulized glutathione pulmonary fibrosis Emerging cellular and molecular determinants of idiopathic | Cellular and Molecular Life Sciences JCI Insight - Attenuation of

Abbreviations ER endoplasmic reticulum IMM inner mitochondrial membrane GCL glutamate-cysteine ligase GPx glutathione peroxidases GR glutathione reductase Grx Glutaredoxin GS glutathione synthetase GSH reduced glutathione GSSG oxidized glutathione GSH/GSSG ratio between reduced and oxidized glutathione GST glutathione S-transferase MOM mitochondrial outer membrane mtGSH mitochondrial glutathione OGC 2-oxoglutarate carrier ROS reactive oxygen species SLC soluble carrier protein TR thioredoxin reductase Trx Thioredoxin xCT cystine/glutamate antiporter SLC7A11 Footnotes Conflicts of interest J.W

1DE) while mitochondrial inner membrane targeted HyPer7 oxidation trended towards increased but did not reach statistical significance (Fig

Karayama M, Masuda J, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, et al

Glutathione should not be taken by children, pets, those who are pregnant or breastfeeding, or those who are allergic to any of the ingredients in glutathione