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In 2023, WADA issued a notification that tramadol would be prohibited in 2024, and as you may have noticed, Global DRO also included a notification in the search results for tramadol throughout 2023 to ensure athletes were informed of this upcoming change
However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions
(PubMed) Choudhury A, Jena A, Jearth V, et al
