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In psychosis, evidence suggests that early-life stress exposures result in aberrant neurodevelopment of brain circuities, including key components of the HPA axis stress response system, such as the amygdala, hippocampus, and medial prefrontal cortex, affecting emotion and regulation of response to stress [26]

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Furthermore, when a mother either contracts a viral infection during pregnancy or acquires a viral infection before pregnancy, this can cause an inflammatory cascade at the maternalfetal interface (115, 127129)

For safety reasons some governments have banned some of these therapeutic agents as the potential for misuse was perceived to be high especially the parenteral use of glutathione for skin whitening practised in some Asian countries