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This process facilitates signal transduction to inform the plant about infection and enables the initiation of a well-directed defense response (in resistance) or partially directed (in tolerance)

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Specifically, the ROS H 2 O 2 oxidizes Fe 2+ to Fe 3+ via the Fenton reaction, forming the highly active hydroxyl radical (OH), inducing oxidative stress and leading to ferroptosis, the accumulation of lipoid-OOH, and the oxidation of polyunsaturated fatty acids (PUFAs) (Kehrer, 2000

Given that developmental programs are well conserved among vertebrate animals, our studies in zebrafish should ultimately lead to a better understanding of the molecular and genetic basis underlying human development