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In addition, a study has revealed that overexpression of miR429 inhibits the NF-B signaling pathway by targeting programmed cell death 4 (PDCD4) to reduce apoptosis and improve cell viability in a CI-AKI cell model (Niu et al., 2021)

3.1.3 Peptides from amphibians with melanin synthesis-inhibiting activities Amphibians produce various peptides with diverse structures and functions, many of which have been studied for their antibacterial, antioxidant, and skin wound-healing properties (McMillan and Coombs, 2020