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Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons
These effects were blocked by sulfasalazine, an inhibitor of the xCT transporter, which incorporates cystine (precursor of GSH) and extrudes extracellular glutamate, an agonist of the inhibitory mGlu2/3 receptor, which lowers the synaptic glutamatergic tone
doi: 10.1016/j.preteyeres.2003.12.001
