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Likewise, MPTP is metabolized into the toxic cation 1-methyl-4-phenylperydinium (MPP + ) [156] by the enzyme MAO-B of glial cells, specifically astrocytes, provides that high-affinity for MPP + affects dopamine transporter (DAT)

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The relevant considerations shift to the biological and practical: mechanism, safety profile, protocol design, and sourcing quality

Symptoms can range from cardiovascular abnormalities like tachycardia and orthostatic hypotension to gastrointestinal issues such as delayed gastric emptying and diabetic constipation or diarrhea