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10.1016/j.intimp.2022.109264 183 ShenF.ZhuangS

10.2174/138161209789271816 37 FernandoR

Attenuation of the IGF-1/AKT pathway in muscle satellite cells from CKD mice leads to reduced levels of myogenic markers, resulting in poor muscle regeneration, fibrosis, and the consequent muscle wasting.134 In hemodialysis patients, it has been recently demonstrated that the association between plasma IGF-1 and muscle strength is comparable to that of the myostatin, a well-known inhibitor of muscle growth, and both similarly predict mortality in this population.135 In this regard, the relationship between higher plasma IGF-1, muscle strength and survival could be expected

That's why stretching just your foot often doesn't work you're pulling on one string while the rest stay knotted