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[9] Multi-disciplinary Review and Evaluation for NDA 215830 Litfulo (ritlecitinib) capsule

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Consequently, there is an accumulation of lipid ROS in vivo, which leads to DNA (48), protein (49) and lipid damage (50), ultimately resulting in cell death

ZSWIM8 displayed binding and polyubiquitylation activity towards another TDMD-competent AGO paralogue, human AGO1 (ref
