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Under glucose-deprived conditions, the knockout of IDH1 or ME1 significantly reduces the NADPH/NADP+ and GSH/oxidized GSH ratios, leading to elevated ROS levels and increased cell death in cancer cells (94)
[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Liu L., Lian N., Shi L., Hao Z., Chen K
Pharmacology & Therapeutics , 190 , 105127
Mechanisms of tau self-aggregation and neurotoxicity
