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Description
Methylation of cytosine at DMRs inhibits the process that pertains to the binding of transcription factors to the locations that are considered regulatory towards the relevant genes, verging on silencing or transcriptional inactivation

used in the before mentioned case from the US, where the patient was fitted with an ICD

Pelletier et al., 2015)
Inflammation can lead to an increase in the production of free radicals in cells, resulting in oxidative stress
