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Unlike -endorphins and enkephalins, dynorphins act on kappa opioid receptors (KORs) and are often released in response to stress
This finding emphasizes the pivotal role of HMGB1 in BUC progression
In addition, many phase 1 clinical trials are testing the efficacy of CAR therapy in solid malignancies by targeting key oncogenic drivers, such as human epidermal growth factor receptor 2 (HER2) and epithelial growth factor receptor (EGFR), which are amplified in many cancers (176)
10.1016/j.etap.2013.07.005
