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Another additional regulatory mechanism involves protein phosphatase 2A (PP2A) that, if eventually inhibited by ROS, is no longer able to dampen Akt/PKB signaling (84)

Thus, the translational regulation of HIF-1 independent of oxygen primarily involves the phosphorylation of ribosomal protein S6 (RPS6) and the eukaryotic initiation factor 4F (eIF4F), similar to the translational regulation of other proteins

[DOI] [PMC free article] [PubMed] [Google Scholar] Mattiazzi, M

97 Clinical implications of antioxidant-enzyme interaction in non-communicable diseases Antioxidant-enzyme interaction in diagnosis and prognosis Antioxidant enzymes and antioxidants are studied and used as biomarkers in the diagnosis and prognosis of several diseases