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Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase

Further studies will be required to make full use of the Grx1-roGFP2-reporter EHM model, which will include investigations of the consequences of specific pharmacological (e.g., simulated neurohumoral overstimulation), biophysical (e.g., controlled electromechanical stimulation), or disease (e.g., hypoxia or ischemia/reoxygenation) stimuli for the ROS-mediated control of heart muscle function

Methods Mice To induce genetic ablation of the GHR, mice carrying loxP-flanked Ghr alleles 44 were bred either with AgRP-IRES-Cre mouse (Agrp tm1(cre)Lowl /J, The Jackson Laboratory), LepR-IRES-Cre mouse (B6.129-Lepr tm2(cre)Rck /J, The Jackson Laboratory) or Nestin-Cre mouse (B6.Cg-Tg (Nes-cre)1Kln /J, The Jackson Laboratory)