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Naunyn Schmiedebergs Arch Pharmacol 398(1):89101 Howitz KT et al (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Before escalating to second- or third-line therapies, clinicians should first evaluate for potential confounding factors such as non-adherence, sub-optimal drug dosing, azathioprine hypermethylation, alternative etiologies, and co-existing conditions like celiac disease, metabolic dysfunction-associated steatotic liver disease, or ASC/overlap syndromes [29, 104]